“Review”-ing Our New Opportunities for “Rapid Report”-ing

"Patch"ing up our tumor signaling knowledge.

The tumor suppressor Patched1 (Ptch1) possesses well-described roles in regulating sonic hedgehog (SHH) signaling in the skin and preventing the formation of basal cell carcinomas (BCCs). In this issue, Kang et al. extend their previous work to show that a naturally occurring allele of Ptch1 found in FVB mice promotes early squamous cell carcinoma (SCC) growth without aberrant activation of the...

Evolut Ionary Schedul Ing and Rout Ing

The aim of this paper is to clearly demonstrate the importance of finding a good balance between genetic search and local search in the implementation of hybrid evolutionary multi-criterion optimization (EMO) algorithms. We first modify the local search part of an existing multi-objective genetic local search (MOGLS) algorithm. In the modified MOGLS algorithm, the computation time spent by loca...

Sli ing for VHDL ?

Ing for Text Classification

Zero-shot Learners are models capable of predicting unseen classes. In this work, we propose a Zero-shot Learning approach for text categorization. Our method involves training model on a large corpus of sentences to learn the relationship between a sentence and its tags. Learning such relationship makes the model generalize to unseen sentences, tags, and even new datasets provided they can be ...

sm"FISH"ing for Hedgehog.

Patched (Ptch) receptors are critical negative regulators of Hedgehog signaling, where Ptch1 loss causes basal cell carcinoma and Ptch1;Ptch2 loss disrupts skin and hair follicle development. Adolphe et al. use single molecule fluorescent in situ hybridization to show quantitatively that Ptch receptors create a Hedgehog signaling gradient that may specify hair follicle development.